SCHEMBL301506

SCHEMBL301506

C=C(C)C(=O)OCCOC(C)C#N

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.49
TSHR P16473 4/20 0.47
ALDH1A1 P00352 3/20 0.35
POLB P06746 1/20 0.34
APEX1 P27695 1/20 0.34
HTT P42858 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL554732 0.80 THRB (0.57) THRBTSHRALDH1A1POLBAPEX1
Water SCHEMBL1765013 0.79 THRB (0.71) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL15006942 0.77 THRB (0.63) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL15636 0.77 THRB (0.74) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL6142874 0.77 THRB (0.74) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL5201539 0.77 THRB (0.53) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL28156518 0.76 THRB (0.42) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL510108 0.76 TSHR (0.50) THRBTSHRALDH1A1
SCHEMBL1533038 0.76 THRB (0.49) THRBTSHRALDH1A1POLBAPEX1
SCHEMBL18979685 0.75 TSHR (0.55) THRBTSHRALDH1A1POLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5409967-A A shell-core polymer blend ROHM AND HAAS COMPANY (US) 1995-04-25 US claimed
EP-0577281-A2 Amorphous, aromatic polyester containing impact modifier ROHM AND HAAS COMPANY (US) 1994-01-05 EP claimed
EP-2265665-B1 FUNCTIONAL MBS IMPACT MODIFIERS FOR USE IN ENGINEERING RESINS ARKEMA INC (US) 2021-10-20 EP disclosed
EP-3387068-B1 THERMOPLASTIC COMPOSITIONS HAVING LOW GLOSS AND HIGH IMPACT STRENGTH COVESTRO LLC (US) 2020-10-28 EP disclosed
US-10640672-B2 Acrylic photovoltaic module backsheet ARKEMA FRANCE (FR) 2020-05-05 US disclosed
US-20190177450-A1 FUNCTIONALIZED BIMODAL IMPACT MODIFIERS ARKEMA INC (US) 2019-06-13 US disclosed
US-10308805-B2 Thermoplastic compositions having low gloss and high impact strength COVESTRO LLC (US) 2019-06-04 US disclosed
EP-2927252-B1 FUNCTIONALIZED BIMODAL IMPACT MODIFIERS ARKEMA INC (US) 2018-10-10 EP disclosed
US-20180273747-A1 THERMOPLASTIC COMPOSITIONS HAVING LOW GLOSS AND HIGH IMPACT STRENGTH COVESTRO LLC 2018-09-27 US disclosed
EP-2404373-B1 ACRYLIC PHOTOVOLTAIC MODULE BACKSHEET ARKEMA FRANCE (FR) 2017-12-20 EP disclosed
US-9249297-B2 Functional MBS impact modifiers for use in engineering resins ARKEMA INC. (US) 2016-02-02 US disclosed
EP-1541603-A1 Core-shell polymers having having hydrophilic shells for improved shell coverage and anti-blocking properties Arkema Inc. (US) 2005-06-15 EP disclosed
US-6316527-B1 FOR PRODUCING INJECTION MOLDED ARTICLES, WILL NOT BREAK WHILE BEING EJECTED FORM MOLD; ELONGATION, IMPACT RESISTANCE AND OPTICAL CLARITY ROHM AND HAAS COMPANY 2001-11-13 US disclosed
EP-1095982-A1 Impact modifier concentrates for amorphous aromatic polyester ROHM AND HAAS COMPANY (US) 2001-05-02 EP disclosed
EP-1085050-A1 Modified san resin blend composition and articles produced therefrom ROHM AND HAAS COMPANY (US) 2001-03-21 EP disclosed
US-6130290-A FOR INCREASING IMPACT RESISTANCE OF POLYESTERS; OPTICAL CLARITY ROHM AND HAAS COMPANY (US) 2000-10-10 US disclosed
EP-0953583-A2 Impact modifier for amorphous aromatic polyester ROHM AND HAAS COMPANY (US) 1999-11-03 EP disclosed
US-5409967-A A shell-core polymer blend ROHM AND HAAS COMPANY (US) 1995-04-25 US disclosed
US-5321056-A Amorphous, aromatic polyester containing impact modifier ROHM AND HAAS COMPANY (US) 1994-06-14 US disclosed
EP-0577281-A2 Amorphous, aromatic polyester containing impact modifier ROHM AND HAAS COMPANY (US) 1994-01-05 EP disclosed