Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.42 |
| ▸ | TET3 | O43151 | 4/20 | 0.42 |
| ▸ | FBXL19 | Q6PCT2 | 4/20 | 0.42 |
| ▸ | CXXC5 | Q7LFL8 | 4/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.42 |
| ▸ | CXXC4 | Q9H2H0 | 4/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.42 |
| ▸ | TET1 | Q8NFU7 | 3/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.39 |
| ▸ | FABP7 | O15540 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119410 | 0.92 | KMT2A (0.49) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL30089214 | 0.89 | KMT2A (0.42) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL22960725 | 0.89 | KMT2A (0.42) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL4870754 | 0.89 | TET3 (0.50) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL4630456 | 0.87 | OPRD1 (0.36) | KMT2AFABP5FABP7MDM2CXCR3 | |
| SCHEMBL3015083 | 0.86 | MEN1 (0.43) | KMT2AFABP5FABP7MEN1RAB9A | |
| SCHEMBL3030476 | 0.85 | HSD11B1 (0.38) | KMT2AFABP5FABP7EPHX2MDM2 | |
| SCHEMBL3032315 | 0.85 | HSD11B1 (0.47) | KMT2AFABP5FABP7EPHX2MDM2 | |
| SCHEMBL7813068 | 0.84 | KMT2A (0.42) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL4630450 | 0.83 | SMN1; SMN2 (0.37) | KMT2AEPHX2MDM2CXCR3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ASTEX THERAPEUTICS LIMITED (GB) | 2010-08-19 | — | — | US | disclosed |
| EP-1919875-A2 | PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS | Astex Therapeutics Limited (GB) | 2008-05-14 | — | — | EP | disclosed |
| EP-1904451-A1 | ARYL-ALKYLAMINES AND HETEROARYL-ALKYLAMINES AS PROTEIN KINASE INHIBITORS | Astex Therapeutics Limited (GB) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006136829-A2 | PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006136830-A1 | ARYL-ALKYLAMINES AND HETEROARYL-ALKYLAMINES AS PROTEIN KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210617-A1 | Aryl-Alkylamines And Heteroaryl-Alkylamines As Protein Kinase Inhibitors | ERBB2, ABL1, GRK2 | KMT2A 26/4885TET3 1657/4885FBXL19 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.