Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 6/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24820539 | 1.00 | P2RY14 (0.39) | P2RY14RXFP1TP53HPGDMAPK1 | |
| SCHEMBL24818855 | 0.91 | VSIR (0.36) | HPGDKDM4ESMN1; SMN2PPARGNPC1 | |
| SCHEMBL30152852 | 0.91 | VSIR (0.36) | HPGDKDM4ESMN1; SMN2PPARGNPC1 | |
| SCHEMBL30152863 | 0.86 | CBLB (0.34) | TP53CD274MAPTPDCD1PDCD1LG2 | |
| SCHEMBL24818981 | 0.86 | CBLB (0.34) | TP53CD274MAPTPDCD1PDCD1LG2 | |
| SCHEMBL24818800 | 0.86 | VSIR (0.38) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL30153011 | 0.86 | VSIR (0.38) | CD274PDCD1PDCD1LG2 | |
| SCHEMBL30153187 | 0.83 | P2RY14 (0.45) | P2RY14RXFP1TP53HPGDKDM4E | |
| SCHEMBL24819976 | 0.83 | P2RY14 (0.45) | P2RY14RXFP1TP53HPGDKDM4E | |
| SCHEMBL24818723 | 0.82 | VSIR (0.36) | TP53CD274PDCD1LMNAPDCD1LG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |