Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24820081 | 1.00 | BRD4 (0.40) | BRD4RHEBMAP3K5SMN1; SMN2KDM4E | |
| SCHEMBL24821830 | 0.85 | BRD4 (0.44) | BRD4RHEBMAP3K5SMN1; SMN2KDM4E | |
| SCHEMBL30153162 | 0.85 | BRD4 (0.37) | BRD4MAP3K5KCNH2SSTR2CBLB | |
| SCHEMBL30153169 | 0.85 | SSTR2 (0.34) | MAP3K5KCNH2SSTR2CBLB | |
| SCHEMBL24821950 | 0.85 | BRD4 (0.37) | BRD4MAP3K5KCNH2SSTR2CBLB | |
| SCHEMBL24820080 | 0.85 | SSTR2 (0.34) | MAP3K5KCNH2SSTR2CBLB | |
| SCHEMBL30152867 | 0.84 | MAPT (0.38) | MAP3K5SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL24818763 | 0.84 | MAPT (0.38) | MAP3K5SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL30792132 | 0.84 | MAPT (0.38) | MAP3K5SMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL24821952 | 0.80 | CBLB (0.34) | KCNH2SSTR2CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |