Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24819891 | 1.00 | SCN9A (0.35) | SCN9ALRRK2SMN1; SMN2ALOX5EPHX2 | |
| SCHEMBL24818853 | 0.90 | SCD (0.35) | SCN9APIM1GUSBCBLBBACE1 | |
| SCHEMBL30152813 | 0.90 | SCD (0.35) | SCN9APIM1GUSBCBLBBACE1 | |
| SCHEMBL29190009 | 0.88 | MAP3K5 (0.34) | LRRK2SMN1; SMN2PIM1CLK1GUSB | |
| SCHEMBL24819889 | 0.87 | CBLB (0.35) | SCN9ASMN1; SMN2PIM1CBLBKDM4E | |
| SCHEMBL24819888 | 0.87 | PIM1 (0.36) | SCN9APIM1CBLBNPBWR1 | |
| SCHEMBL30152668 | 0.87 | PIM1 (0.36) | SCN9APIM1CBLBNPBWR1 | |
| SCHEMBL30153255 | 0.87 | CBLB (0.35) | SCN9ASMN1; SMN2PIM1CBLBKDM4E | |
| SCHEMBL24818783 | 0.85 | CHEK2 (0.35) | SCN9ACBLB | |
| SCHEMBL24821802 | 0.85 | ADORA2A (0.39) | SMN1; SMN2BACE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| CN-117858865-A | CBL-B modulators and uses thereof | 林伯士克莱奥公司 | 2024-04-09 | — | — | CN | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |