Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24821830 | 0.93 | BRD4 (0.44) | MMP2MMP9MMP8MMP13HDAC6 | |
| SCHEMBL30152881 | 0.83 | NPC1 (0.46) | KDM4EALDH1A1NPC1PKMHPGD | |
| SCHEMBL24818670 | 0.83 | NPC1 (0.46) | KDM4EALDH1A1NPC1PKMHPGD | |
| SCHEMBL24820013 | 0.82 | MAPT (0.48) | KDM4EALDH1A1LMNANPC1PKM | |
| SCHEMBL24820343 | 0.82 | RAB9A (0.46) | HDAC6KDM4EALDH1A1NPC1HPGD | |
| SCHEMBL24818715 | 0.80 | MAPT (0.45) | HDAC6KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL24820653 | 0.80 | HDAC6 (0.42) | HDAC6KDM4ELMNANPC1PKM | |
| SCHEMBL24820081 | 0.79 | BRD4 (0.40) | MMP2MMP9MMP8MMP13BRD4 | |
| SCHEMBL30152703 | 0.79 | BRD4 (0.40) | MMP2MMP9MMP8MMP13BRD4 | |
| SCHEMBL24818859 | 0.78 | GUSB (0.36) | KDM4ELMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359381-A1 | CBL-B MODULATORS AND USES THEREOF | Nimbus Clio, Inc. (US) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022272248-A1 | CBL-B MODULATORS AND USES THEREOF | NIMBUS CLIO, INC. (US) | 2022-12-29 | — | — | WO | disclosed |