SCHEMBL30153149

SCHEMBL30153149

Cn1cnnc1-c1cc(F)ccc1-c1ccnc(-c2nc3cc(CO)cc(C(F)(F)F)c3o2)c1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ WNT3A P56704 3/20 0.32
▸ ABL1 P00519 1/20 0.32
▸ CETP P11597 1/20 0.31
▸ CBLB Q13191 1/20 0.31
▸ KDM4C Q9H3R0 1/20 0.30
▸ VSIR Q9H7M9 1/20 0.30
▸ KDM2B Q8NHM5 1/20 0.30
▸ PHF8 Q9UPP1 1/20 0.30
▸ KDM5B Q9UGL1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24820528 1.00 WNT3A (0.32) WNT3AABL1CETPCBLBKDM4C
SCHEMBL24819029 0.92 KDM4C (0.34) CETPCBLBKDM4CKDM5B
SCHEMBL24818674 0.88 VSIR (0.40) CETPCBLBVSIR
SCHEMBL24821930 0.88 CBLB (0.39) CBLB
SCHEMBL30152647 0.86 IDO1 (0.30) —
SCHEMBL24820526 0.86 IDO1 (0.30) —
SCHEMBL29190107 0.86 CBLB (0.31) CBLB
SCHEMBL30152945 0.86 CBLB (0.31) CBLB
SCHEMBL24820270 0.85 CBLB (0.35) CBLB
SCHEMBL30153126 0.85 CBLB (0.35) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. 2025-05-22 — — US disclosed
EP-4359381-A1 CBL-B MODULATORS AND USES THEREOF Nimbus Clio, Inc. (US) 2024-05-01 — — EP disclosed
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
WO-2022272248-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. (US) 2022-12-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF CBLB, CBL, CBLC WNT3A 1888/4885ABL1 776/4885CETP 3617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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