Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | BLVRB | P30043 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60690 | 1.00 | NPC1 (0.63) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL59529 | 0.87 | NPC1 (0.67) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL60775 | 0.86 | NPC1 (0.59) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL59247 | 0.86 | RAB9A (0.72) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL60427 | 0.86 | NPC1 (0.76) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL59426 | 0.85 | NPC1 (0.67) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL17336565 | 0.84 | NPC1 (0.72) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL60333 | 0.83 | MAOA (0.68) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL5345798 | 0.83 | NPC1 (0.80) | NPC1RAB9AL3MBTL1NR1H4MAOA | |
| SCHEMBL60606 | 0.83 | NPC1 (0.67) | NPC1RAB9AL3MBTL1NR1H4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101846-A1 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PTC Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |