Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2723062 | 1.00 | TRPV4 (0.44) | TRPV4AKR1B1RXRARXRBRXRG | |
| SCHEMBL297085 | 0.85 | MRGPRX4 (0.41) | TRPV4AKR1B1RXRARXRBRXRG | |
| SCHEMBL2730017 | 0.81 | HSD17B10 (0.48) | AKR1B1CXCL8TSHRTDP1 | |
| SCHEMBL286608 | 0.81 | STING1 (0.44) | PTGDR2TSHRTDP1 | |
| SCHEMBL23832263 | 0.80 | MAPT (0.40) | TRPV4AKR1B1TSHR | |
| SCHEMBL30154484 | 0.80 | MAPT (0.40) | TRPV4AKR1B1TSHR | |
| SCHEMBL332576 | 0.78 | CXCL8 (0.43) | AKR1B1CXCL8DPP4TSHRPKM | |
| SCHEMBL29362137 | 0.78 | CXCL8 (0.43) | AKR1B1CXCL8DPP4TSHRPKM | |
| SCHEMBL365265 | 0.77 | TRPV4 (0.50) | TRPV4AKR1B1 | |
| SCHEMBL13766377 | 0.77 | TRPV4 (0.50) | TRPV4AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119823097-A | PHD inhibitor compounds, compositions and uses | 阿克比治疗有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-115551845-B | PHD inhibitor compounds, compositions and uses | 阿克比治疗有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-115551845-A | PHD inhibitor compounds, compositions and uses | 阿克比治疗有限公司 | 2022-12-30 | — | — | CN | disclosed |