Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CFB | P00751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18658940 | 0.85 | GRIN2B (0.41) | GRIN2BLRRK2GRIN1 | |
| SCHEMBL18658935 | 0.85 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL18606421 | 0.83 | PDE10A (0.36) | KMT2APDE10A | |
| SCHEMBL30154553 | 0.82 | LRRK2 (0.53) | GRIN2BLRRK2GRIN1 | |
| SCHEMBL18606424 | 0.82 | LRRK2 (0.53) | GRIN2BLRRK2GRIN1 | |
| SCHEMBL18606559 | 0.79 | KMT2A (0.36) | KMT2AKRASACVR1MAPT | |
| SCHEMBL18606548 | 0.75 | KRAS (0.38) | KMT2AKRASPDE10AACVR1MAPT | |
| SCHEMBL18606517 | 0.74 | SMN1; SMN2 (0.41) | KMT2AKRASACVR1MAPT | |
| SCHEMBL30154915 | 0.73 | LRRK2 (0.36) | LRRK2KMT2AKRASPDE10AACVR1 | |
| SCHEMBL18658957 | 0.73 | GABRA1 (0.34) | LRRK2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111051304-B | Imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2022-12-27 | — | — | CN | disclosed |