Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30155305 | 0.97 | SIGMAR1 (0.33) | SIGMAR1JAK1JAK2LMNAPOLB | |
| SCHEMBL30155475 | 0.80 | LMNA (0.35) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL22626384 | 0.77 | TSHR (0.42) | SIGMAR1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL30835505 | 0.77 | SMN1; SMN2 (0.49) | SIGMAR1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL6340824 | 0.75 | POLB (0.41) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL1005888 | 0.73 | USP2 (0.41) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL29535838 | 0.73 | POLB (0.45) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4910507 | 0.72 | HPGD (0.41) | SIGMAR1SMN1; SMN2 | |
| SCHEMBL6820687 | 0.72 | POLB (0.44) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL1972696 | 0.71 | POLB (0.41) | LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359081-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | Novartis AG (CH) | 2024-05-01 | — | — | EP | disclosed |
| WO-2022269508-A1 | PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN | NOVARTIS AG (CH) | 2022-12-29 | — | — | WO | disclosed |