Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 15/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.35 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25084763 | 1.00 | PDCD1 (0.43) | PDCD1CD274TGFBR1TLR8TLR7 | |
| SCHEMBL25084626 | 0.89 | PDCD1 (0.42) | PDCD1CD274TGFBR1TLR8TLR7 | |
| SCHEMBL30156037 | 0.89 | PDCD1 (0.42) | PDCD1CD274TGFBR1TLR8TLR7 | |
| SCHEMBL30155714 | 0.84 | TGFBR1 (0.43) | TGFBR1TGFBR2MAP3K20CYP2D6 | |
| SCHEMBL25084814 | 0.84 | TGFBR1 (0.43) | TGFBR1TGFBR2MAP3K20CYP2D6 | |
| SCHEMBL25084705 | 0.83 | TGFBR1 (0.39) | TGFBR1TGFBR2MAP3K20CYP2D6THRB | |
| SCHEMBL30155878 | 0.83 | TGFBR1 (0.39) | TGFBR1TGFBR2MAP3K20CYP2D6THRB | |
| SCHEMBL25085181 | 0.80 | CHRNB2 (0.44) | TGFBR1PIM1 | |
| SCHEMBL30156324 | 0.80 | CHRNB2 (0.44) | TGFBR1PIM1 | |
| SCHEMBL25084666 | 0.77 | PDCD1 (0.38) | PDCD1CD274TGFBR1TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11590116-B2 | Substituted pyridines and methods of use | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2023-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11590116-B2 | Substituted pyridines and methods of use | ALK, ACVR1, ACVR2A | PDCD1 3348/4885CD274 3380/4885TGFBR1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.