Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | UGCG | Q16739 | 5/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3015635 | 1.00 | PTGS1 (0.60) | PTGS1PTGS2HTTAOC3TSHR | |
| SCHEMBL30695666 | 1.00 | PTGS1 (0.60) | PTGS1PTGS2HTTAOC3TSHR | |
| SCHEMBL3006190 | 0.85 | OGA (0.43) | PTGS1PTGS2HTT | |
| SCHEMBL3006193 | 0.85 | OGA (0.43) | PTGS1PTGS2HTT | |
| SCHEMBL411326 | 0.82 | PTGS1 (0.49) | PTGS1PTGS2HTTAOC3TSHR | |
| SCHEMBL22478451 | 0.81 | PTGS1 (0.69) | PTGS1PTGS2HTTAOC3TSHR | |
| SCHEMBL22463682 | 0.81 | PTGS1 (0.50) | PTGS1PTGS2HTTAOC3CYP3A4 | |
| SCHEMBL22463681 | 0.81 | PTGS1 (0.50) | PTGS1PTGS2HTTAOC3CYP3A4 | |
| SCHEMBL836851 | 0.79 | PTGS1 (0.49) | PTGS1PTGS2HTTAOC3CYP3A4 | |
| SCHEMBL19287220 | 0.79 | UGCG (0.68) | PTGS1PTGS2HTTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738632-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2017-08-22 | — | — | US | disclosed |
| US-20170081315-A1 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2017-03-23 | — | — | US | disclosed |
| US-9512110-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2016-12-06 | — | — | US | disclosed |
| EP-2291369-B1 | BENZODIOXINYL SUBSTITUTED INDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-11-04 | — | — | EP | disclosed |
| US-20150080434-A1 | PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES | ASTRAZENECA AB (SE) | 2015-03-19 | — | — | US | disclosed |
| US-8916600-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2014-12-23 | — | — | US | disclosed |
| EP-2620435-A1 | Phenyl and benzodioxinyl substituted indazole derivatives | Astrazeneca AB (SE) | 2013-07-31 | — | — | EP | disclosed |
| US-20120302617-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | ASTRAZENECA AB (SE) | 2012-11-29 | — | — | US | disclosed |
| US-20120252770-A1 | Chemical Compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-04 | — | — | US | disclosed |
| US-8211930-B2 | Phenyl and benzodioxinyl substituted indazoles derivatives | ASTRAZENECA AB (SE) | 2012-07-03 | — | — | US | disclosed |
| EP-2102169-B1 | INDAZOLYL AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2012-06-20 | — | — | EP | disclosed |
| US-20100197644-A1 | Chemical Compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-05 | — | — | US | disclosed |
| US-7728030-B2 | Chemical compounds 572 | ASTRAZENECA AB (SE) | 2010-06-01 | — | — | US | disclosed |
| US-20100087489-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-08 | — | — | US | disclosed |
| US-20080214641-A1 | Chemical compounds 572 | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214641-A1 | Chemical compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885HTT 4179/4885 |
| US-20100197644-A1 | Chemical Compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885HTT 4179/4885 |
| US-20120302617-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | CYP3A5, CYP4X1, CYP3A7 | PTGS1 157/4885PTGS2 183/4885HTT 4165/4885 |
| US-20150080434-A1 | PHENYL AND BENZODIOXINYL SUBSTITUTED INDAZOLES DERIVATIVES | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885HTT 4314/4885 |
| US-20100087489-A1 | Phenyl and Benzodioxinyl Substituted Indazoles Derivatives | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885HTT 4314/4885 |
| US-20120252770-A1 | Chemical Compounds 572 | ABCG2, ABCB1, CYP11B2 | PTGS1 168/4885PTGS2 72/4885HTT 4179/4885 |
| US-20170081315-A1 | Phenyl and benzodioxinyl substituted indazoles derivatives | CYP3A5, ABCB1, CYP4X1 | PTGS1 105/4885PTGS2 104/4885HTT 4314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.