Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | IL1B | P01584 | 8/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | F12 | P00748 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27224459 | 1.00 | NLRP3 (0.62) | NLRP3KCNH2IL1BTNFF12 | |
| SCHEMBL27224407 | 0.87 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30156937 | 0.87 | NLRP3 (0.67) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30157058 | 0.86 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNFRBP4 | |
| SCHEMBL27224451 | 0.86 | NLRP3 (0.63) | NLRP3KCNH2IL1BTNFRBP4 | |
| SCHEMBL30157075 | 0.83 | NLRP3 (0.72) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224458 | 0.83 | NLRP3 (0.72) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL30157063 | 0.83 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL26438471 | 0.83 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNF | |
| SCHEMBL27224408 | 0.83 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118234711-A | Cyclopyridazine compounds | 尼科治疗有限公司 | 2024-06-21 | — | — | CN | disclosed |
| EP-4375274-A1 | ANNULATED PYRIDAZINE COMPOUND | Nico Therapeutics, Inc. (US) | 2024-05-29 | — | — | EP | disclosed |
| WO-2023003002-A1 | ANNULATED PYRIDAZINE COMPOUND | アステラス製薬株式会社 | 2023-01-26 | — | — | WO | disclosed |