Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | IL1B | P01584 | 6/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30987279 | 0.87 | NLRP3 (0.59) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL30356551 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL30624986 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL30181078 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL24855752 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL24855439 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL24855753 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL24855438 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL30181196 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 | |
| SCHEMBL30180967 | 0.82 | NLRP3 (0.74) | NLRP3KCNH2IL1BTNFCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023003002-A1 | ANNULATED PYRIDAZINE COMPOUND | アステラス製薬株式会社 | 2023-01-26 | — | — | WO | disclosed |