SCHEMBL30157766

SCHEMBL30157766

O=C(NCc1ccccc1Cl)C1CC(=O)N(C2CCCC2)C1

nearest known ligand 0.73

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.73
CYP2C19 P33261 2/20 0.73
CYP2C9 P11712 2/20 0.73
SMN1; SMN2 Q16637 2/20 0.71
LMNA P02545 1/20 0.71
HTT P42858 1/20 0.71
P2RX7 Q99572 3/20 0.71
GAA P10253 1/20 0.64
KMT2A Q03164 3/20 0.64
ALDH1A1 P00352 7/20 0.62
MEN1 O00255 1/20 0.62
TSHR P16473 2/20 0.61
CYP2D6 P10635 2/20 0.60
CYP1A2 P05177 1/20 0.60
CASP1 P29466 1/20 0.60
CASP7 P55210 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30157599 0.98 P2RX7 (0.71) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA
SCHEMBL30157405 0.85 P2RX7 (0.92) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA
SCHEMBL30157935 0.83 CYP3A4 (0.66) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA
SCHEMBL3748304 0.83 P2RX7 (1.00) P2RX7
SCHEMBL30157718 0.82 SMN1; SMN2 (0.93) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA
SCHEMBL3752428 0.81 P2RX7 (1.00) CYP2C19P2RX7CYP2D6
SCHEMBL30157691 0.80 ALDH1A1 (0.73) CYP3A4CYP2C19SMN1; SMN2LMNAHTT
SCHEMBL30157898 0.80 SMN1; SMN2 (0.69) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA
SCHEMBL30157734 0.79 GAA (0.63) LMNAP2RX7GAAKMT2AALDH1A1
SCHEMBL30157820 0.79 SMN1; SMN2 (0.67) CYP3A4CYP2C19CYP2C9SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268520-A1 USE OF SUBSTITUTED PYRROLIDINONES OR THEIR SALTS FOR INCREASING STRESS TOLERANCE OF PLANTS BAYER AKTIENGESELLSCHAFT (DE) 2022-12-29 WO disclosed