SCHEMBL30157798

SCHEMBL30157798

O=C(NCc1cccc(Cl)c1Cl)C1CC(=O)N(Cc2ccc3c(c2)OCO3)C1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.62
ALDH1A1 P00352 6/20 0.61
TSHR P16473 2/20 0.61
P2RX7 Q99572 5/20 0.59
GAA P10253 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
KMT2A Q03164 1/20 0.56
MGLL Q99685 1/20 0.55
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CASP1 P29466 1/20 0.55
CYP2C19 P33261 1/20 0.55
CASP7 P55210 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.49
ALDH2 P05091 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30157445 0.85 P2RX7 (0.78) ALDH1A1P2RX7KMT2ASMN1; SMN2
SCHEMBL30157775 0.78 P2RX7 (0.82) ALDH1A1P2RX7KMT2AL3MBTL1SMN1; SMN2
SCHEMBL22366557 0.78 HPGD (1.00) HPGDALDH1A1TSHRKMT2ACYP1A2
SCHEMBL3750944 0.74 P2RX7 (1.00) P2RX7
SCHEMBL30158761 0.73 P2RX7 (0.84) ALDH1A1P2RX7SMN1; SMN2
SCHEMBL3664155 0.73 P2RX7 (1.00) ALDH1A1P2RX7SMN1; SMN2
SCHEMBL10107742 0.69 ALDH2 (0.77) HPGDALDH1A1TSHRTDP1KMT2A
SCHEMBL20506353 0.69 P2RX7 (0.58) ALDH1A1TSHRP2RX7KMT2AL3MBTL1
SCHEMBL3749986 0.68 P2RX7 (1.00) P2RX7
SCHEMBL20596867 0.68 P2RX7 (0.57) HPGDALDH1A1TSHRP2RX7KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022268520-A1 USE OF SUBSTITUTED PYRROLIDINONES OR THEIR SALTS FOR INCREASING STRESS TOLERANCE OF PLANTS BAYER AKTIENGESELLSCHAFT (DE) 2022-12-29 WO disclosed