Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24991324 | 0.91 | LMNA (0.81) | SMN1; SMN2LMNAL3MBTL1MAPTTSHR | |
| SCHEMBL30159302 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1MAPTNAAA | |
| SCHEMBL14288941 | 0.84 | LMNA (0.69) | SMN1; SMN2LMNAL3MBTL1MAPTTSHR | |
| SCHEMBL18970362 | 0.82 | LMNA (0.71) | SMN1; SMN2LMNAL3MBTL1MAPTTSHR | |
| SCHEMBL16302062 | 0.82 | SMN1; SMN2 (0.85) | SMN1; SMN2LMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL30159491 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAL3MBTL1MAPTTSHR | |
| SCHEMBL29399108 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAL3MBTL1MAPTNPC1 | |
| SCHEMBL15164979 | 0.81 | SMN1; SMN2 (0.83) | SMN1; SMN2LMNAL3MBTL1MAPTNPC1 | |
| SCHEMBL5110887 | 0.81 | NPC1 (0.63) | SMN1; SMN2LMNAMAPTNPC1RAB9A | |
| SCHEMBL3508948 | 0.81 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAL3MBTL1MAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110776-A1 | NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2023-01-04 | — | — | EP | disclosed |