Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30159302 | 0.91 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1LMNAALDH1A1CYP3A4 | |
| SCHEMBL30316654 | 0.83 | L3MBTL1 (0.50) | SMN1; SMN2L3MBTL1LMNATDP1MAPT | |
| SCHEMBL12088080 | 0.83 | HTT (0.67) | SMN1; SMN2L3MBTL1LMNACHRNB2CHRNB4 | |
| SCHEMBL30159248 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2L3MBTL1LMNAALDH1A1CYP3A4 | |
| SCHEMBL12653650 | 0.79 | HTT (0.62) | SMN1; SMN2L3MBTL1LMNACHRNB2CHRNB4 | |
| SCHEMBL23016769 | 0.79 | HTT (0.54) | SMN1; SMN2L3MBTL1LMNAALDH1A1HTT | |
| SCHEMBL17771999 | 0.78 | HTT (0.72) | SMN1; SMN2L3MBTL1LMNAHTTMAPT | |
| SCHEMBL18081347 | 0.77 | HTT (0.59) | SMN1; SMN2L3MBTL1LMNAHTTMAPT | |
| SCHEMBL14288941 | 0.77 | LMNA (0.69) | SMN1; SMN2L3MBTL1LMNAALDH1A1CYP3A4 | |
| SCHEMBL28855527 | 0.77 | LMNA (0.54) | SMN1; SMN2L3MBTL1LMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110776-A1 | NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2023-01-04 | — | — | EP | disclosed |