Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.39 |
| ▸ | NCF1 | P14598 | 4/20 | 0.33 |
| ▸ | NCK1 | P16333 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954184 | 0.68 | METTL3 (0.39) | METTL3PRMT5WDR77 | |
| SCHEMBL24954215 | 0.68 | METTL3 (0.39) | METTL3PRMT5WDR77 | |
| SCHEMBL30159529 | 0.67 | BACE1 (0.37) | BACE1NCF1NCK1NOS2METTL3 | |
| SCHEMBL30159566 | 0.66 | METTL3 (0.50) | METTL3PRMT5WDR77 | |
| SCHEMBL30159329 | 0.65 | PRMT5 (0.51) | BACE1NCF1NOS2METTL3PLAU | |
| SCHEMBL30159412 | 0.65 | METTL3 (0.52) | NCF1METTL3PRMT5WDR77 | |
| SCHEMBL4502570 | 0.59 | BACE1 (0.73) | BACE1NCF1NOS2PLAU | |
| SCHEMBL30499285 | 0.59 | BACE1 (0.57) | BACE1NCF1NCK1NOS2PLAU | |
| SCHEMBL11973788 | 0.59 | BACE1 (0.57) | BACE1NCF1NCK1NOS2PLAU | |
| SCHEMBL7049649 | 0.59 | BACE1 (0.73) | BACE1NCF1NCK1NOS2PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001133-A1 | PRMT5 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2023-01-26 | — | — | WO | disclosed |