⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572137 | 0.75 | TLR7 (0.36) | — | |
| SCHEMBL29119545 | 0.73 | PRMT5 (0.42) | — | |
| SCHEMBL30159402 | 0.73 | PRMT5 (0.42) | — | |
| SCHEMBL24953043 | 0.73 | PRMT5 (0.42) | — | |
| SCHEMBL29119544 | 0.73 | PRMT5 (0.42) | — | |
| SCHEMBL22002181 | 0.72 | KDM4E (0.45) | — | |
| SCHEMBL30159529 | 0.71 | BACE1 (0.37) | — | |
| SCHEMBL24954220 | 0.70 | PRMT5 (0.41) | — | |
| SCHEMBL30159403 | 0.70 | TLR7 (0.47) | — | |
| SCHEMBL30159268 | 0.69 | PRMT5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001133-A1 | PRMT5 INHIBITOR | 上海齐鲁制药研究中心有限公司 | 2023-01-26 | — | — | WO | disclosed |