Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536716 | 0.86 | GPR119 (0.41) | GPR119SIRT2SIRT1ALDH1A1TRPA1 | |
| SCHEMBL23536802 | 0.86 | GPR119 (0.41) | GPR119SIRT2SIRT1ALDH1A1TRPA1 | |
| SCHEMBL29058474 | 0.83 | GPR119 (0.39) | GPR119SIRT2SIRT1ALDH1A1USP2 | |
| SCHEMBL23594160 | 0.82 | GPR119 (0.39) | GPR119SIRT2SIRT1ALDH1A1TRPA1 | |
| SCHEMBL23536803 | 0.80 | USP30 (0.35) | GPR119LMNAUSP30 | |
| SCHEMBL28527377 | 0.80 | GPR119 (0.46) | GPR119ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL23536816 | 0.79 | NR1H2 (0.39) | ALDH1A1TSHRMEN1KMT2ALMNA | |
| SCHEMBL23536819 | 0.79 | SIRT2 (0.33) | GPR119SIRT2SIRT1TRPA1LMNA | |
| SCHEMBL5536717 | 0.77 | ALDH1A1 (0.55) | GPR119ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL1943999 | 0.77 | USP2 (0.44) | GPR119ALDH1A1USP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077309-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas Operations, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |