Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | CDK7 | P50613 | 1/20 | 0.68 |
| ▸ | CCNH | P51946 | 1/20 | 0.68 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.54 |
| ▸ | EDNRB | P24530 | 2/20 | 0.53 |
| ▸ | EDNRA | P25101 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25453798 | 1.00 | CDK1 (0.68) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL13615072 | 0.80 | CDK1 (0.63) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL13629329 | 0.80 | ALDH1A1 (0.65) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL14403379 | 0.77 | MEN1 (0.62) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL16325537 | 0.75 | CDK1 (0.65) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL31689483 | 0.75 | CES1 (0.62) | ALDH1A1MAPTTDP1IDH1 | |
| SCHEMBL29561662 | 0.75 | PKM (0.53) | — | |
| SCHEMBL22095989 | 0.75 | MAPK1 (0.71) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL29118839 | 0.75 | ALDH1A1 (0.67) | CDK1CCNB1CCNA2CDK2CDK7 | |
| SCHEMBL95927 | 0.75 | ALDH1A1 (0.67) | CDK1CCNB1CCNA2CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768750-A | GCN2 modulator compounds | 阿莱斯塔治疗公司 | 2023-03-07 | — | — | CN | disclosed |
| EP-4107146-A1 | GCN2 MODULATOR COMPOUNDS | Alesta Therapeutics BV (NL) | 2022-12-28 | — | — | EP | disclosed |