Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699375 | 1.00 | TP53 (0.43) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL30610187 | 0.86 | MEN1 (0.43) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL17731773 | 0.86 | MEN1 (0.43) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL20699344 | 0.86 | GPR119 (0.42) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL30161700 | 0.86 | GPR119 (0.42) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL22198743 | 0.84 | IDO1 (0.48) | MEN1KMT2AKRASGPR119 | |
| SCHEMBL21894615 | 0.79 | JAK1 (0.47) | NR3C1KRAS | |
| SCHEMBL20939467 | 0.78 | KRAS (0.40) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL22584461 | 0.78 | KRAS (0.40) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL22584459 | 0.78 | KRAS (0.40) | TP53LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032646-B | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2023-01-03 | — | — | CN | disclosed |