Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699344 | 1.00 | GPR119 (0.42) | GPR119RXRARXRBRXRGTGFBR1 | |
| SCHEMBL20699375 | 0.86 | TP53 (0.43) | GPR119LMNATP53MAPTKRAS | |
| SCHEMBL30161908 | 0.86 | TP53 (0.43) | GPR119LMNATP53MAPTKRAS | |
| SCHEMBL21486175 | 0.85 | RXRA (0.40) | RXRARXRBRXRGATRKRAS | |
| SCHEMBL20711771 | 0.85 | GPR119 (0.43) | GPR119RXRARXRBRXRGTGFBR1 | |
| SCHEMBL29607199 | 0.85 | GPR119 (0.43) | GPR119RXRARXRBRXRGTGFBR1 | |
| SCHEMBL29608306 | 0.83 | PIK3CD (0.40) | GPR119RXRARXRBRXRGPIK3CA | |
| SCHEMBL20699398 | 0.83 | RXRA (0.41) | GPR119RXRARXRBRXRGATR | |
| SCHEMBL20711775 | 0.83 | PIK3CD (0.40) | GPR119RXRARXRBRXRGPIK3CA | |
| SCHEMBL30161515 | 0.83 | RXRA (0.41) | GPR119RXRARXRBRXRGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032646-B | Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors | 施万生物制药研发IP有限责任公司 | 2023-01-03 | — | — | CN | disclosed |