Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.49 |
| ▸ | CCND1 | P24385 | 7/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP4 | P49662 | 2/20 | 0.41 |
| ▸ | CASP5 | P51878 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24851179 | 1.00 | CDK4 (0.49) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL24851155 | 0.97 | CDK4 (0.45) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL30161933 | 0.97 | CDK4 (0.45) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL30161986 | 0.86 | CASP1 (0.46) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL24852373 | 0.86 | CASP1 (0.46) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL24851095 | 0.85 | CDK4 (0.43) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL30161877 | 0.85 | CDK4 (0.43) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL24851900 | 0.84 | CDK4 (0.44) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL30162011 | 0.84 | CDK4 (0.44) | CDK4CCND1CDK6CASP1CASP4 | |
| SCHEMBL24851285 | 0.83 | PIM1 (0.45) | CASP1CASP4CASP5PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278483-A1 | COMPOUNDS HAVING 1H-PYRAZOLO[4,3-C]PYRIDIN-6-AMINOS AS THERAPEUTIC AGENTS | LOMOND THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |