Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163045 | 0.81 | ROCK2 (0.51) | MAPKAPK2ROCK2TGFBR1KDREGFR | |
| SCHEMBL29218319 | 0.81 | ROCK2 (0.51) | MAPKAPK2ROCK2TGFBR1KDREGFR | |
| SCHEMBL30162873 | 0.79 | ROCK2 (0.49) | MAPKAPK2ROCK2TGFBR1EGFRMKNK1 | |
| SCHEMBL30163209 | 0.78 | ROCK2 (0.48) | MAPKAPK2ROCK2TGFBR1EGFRMKNK1 | |
| SCHEMBL30163049 | 0.77 | JAK3 (0.59) | JAK3ROCK2KDRKDM4EMEN1 | |
| SCHEMBL29218270 | 0.77 | JAK3 (0.59) | JAK3ROCK2KDRKDM4EMEN1 | |
| SCHEMBL30162998 | 0.77 | JAK3 (0.55) | JAK3ROCK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL29218207 | 0.77 | JAK3 (0.55) | JAK3ROCK2KDM4EMEN1ALDH1A1 | |
| SCHEMBL18114539 | 0.72 | ROCK2 (0.67) | MAPKAPK2ROCK2ROCK1 | |
| SCHEMBL24933417 | 0.70 | ROCK2 (0.63) | MAPKAPK2JAK3ROCK2KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |