Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163154 | 0.84 | ROCK2 (0.56) | ROCK2TGFBR1ROCK1KDM4EMEN1 | |
| SCHEMBL29218214 | 0.84 | ROCK2 (0.56) | ROCK2TGFBR1ROCK1KDM4EMEN1 | |
| SCHEMBL30163015 | 0.78 | MAPKAPK2 (0.51) | ROCK2EGFRMKNK1TGFBR1MAPKAPK2 | |
| SCHEMBL24934134 | 0.78 | ROCK2 (0.44) | ROCK2ROCK1KDM4EMEN1ALDH1A1 | |
| SCHEMBL30163061 | 0.77 | ROCK2 (0.51) | ROCK2ROCK1MEN1KMT2ARAB9A | |
| SCHEMBL29218185 | 0.77 | ROCK2 (0.51) | ROCK2ROCK1MEN1KMT2ARAB9A | |
| SCHEMBL24934132 | 0.77 | NPC1 (0.50) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL30162873 | 0.76 | ROCK2 (0.49) | ROCK2EGFRMKNK1TGFBR1MAPKAPK2 | |
| SCHEMBL29218319 | 0.75 | ROCK2 (0.51) | ROCK2EGFRMKNK1TGFBR1MAPKAPK2 | |
| SCHEMBL30163045 | 0.75 | ROCK2 (0.51) | ROCK2EGFRMKNK1TGFBR1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |