Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | STK3 | Q13188 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934071 | 1.00 | ACHE (0.41) | ACHEROCK1QPCTROCK2TP53 | |
| SCHEMBL30162929 | 0.86 | ROCK2 (0.39) | ROCK1ROCK2TP53SMN1; SMN2MAPT | |
| SCHEMBL29218243 | 0.86 | ROCK2 (0.39) | ROCK1ROCK2TP53SMN1; SMN2MAPT | |
| SCHEMBL24934078 | 0.85 | POLB (0.40) | ROCK1ROCK2TP53SMN1; SMN2MAPT | |
| SCHEMBL21217759 | 0.84 | ROCK2 (0.42) | ROCK1ROCK2SMN1; SMN2CLK2BLK | |
| SCHEMBL21217512 | 0.82 | ROCK2 (0.41) | ROCK1ROCK2SMN1; SMN2CLK2BLK | |
| SCHEMBL21217515 | 0.82 | ROCK2 (0.40) | ROCK1ROCK2SMN1; SMN2CLK2BLK | |
| SCHEMBL22966767 | 0.80 | ROCK2 (0.41) | ROCK1ROCK2SMN1; SMN2MEN1MAPT | |
| SCHEMBL21218005 | 0.80 | ROCK2 (0.40) | ROCK1ROCK2SMN1; SMN2CLK2BLK | |
| SCHEMBL29218276 | 0.79 | SLC2A1 (0.49) | ACHEROCK1QPCTROCK2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |