Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 12/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218262 | 1.00 | RXRA (0.40) | RXRARXRBRXRGATRMAPK13 | |
| SCHEMBL30162841 | 0.89 | RXRA (0.41) | RXRARXRBRXRGMAPK13MAPK8 | |
| SCHEMBL29218215 | 0.89 | RXRA (0.41) | RXRARXRBRXRGMAPK13MAPK8 | |
| SCHEMBL30163099 | 0.82 | RXRA (0.39) | RXRARXRBRXRGEGFRSYK | |
| SCHEMBL29218242 | 0.82 | RXRA (0.39) | RXRARXRBRXRGEGFRSYK | |
| SCHEMBL30163081 | 0.81 | RXRA (0.43) | RXRARXRBRXRGMAPK13MAPK8 | |
| SCHEMBL30163129 | 0.78 | RXRA (0.41) | RXRARXRBRXRG | |
| SCHEMBL29218301 | 0.77 | RXRA (0.39) | RXRARXRBRXRGATRMAPK13 | |
| SCHEMBL30163082 | 0.77 | RXRA (0.39) | RXRARXRBRXRGATRMAPK13 | |
| SCHEMBL30163058 | 0.76 | GRM4 (0.39) | GRM4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |