Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 7/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29218242 | 1.00 | RXRA (0.39) | RXRARXRBRXRGSYKKCNH2 | |
| SCHEMBL30162987 | 0.89 | RXRA (0.40) | RXRARXRBRXRGAURKAAURKB | |
| SCHEMBL29218334 | 0.89 | RXRA (0.40) | RXRARXRBRXRGAURKAAURKB | |
| SCHEMBL29218281 | 0.82 | RXRA (0.40) | RXRARXRBRXRGROCK1 | |
| SCHEMBL30163011 | 0.82 | RXRA (0.40) | RXRARXRBRXRGROCK1 | |
| SCHEMBL29218262 | 0.82 | RXRA (0.40) | RXRARXRBRXRGSYKEGFR | |
| SCHEMBL30163121 | 0.82 | RXRA (0.40) | RXRARXRBRXRGSYKEGFR | |
| SCHEMBL29218297 | 0.81 | ABL1 (0.35) | RXRARXRBRXRGSYKAURKA | |
| SCHEMBL29218192 | 0.80 | ROCK2 (0.46) | SYKEGFRAURKBABL1KDR | |
| SCHEMBL30163093 | 0.80 | ROCK2 (0.46) | SYKEGFRAURKBABL1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |