Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 10/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934290 | 0.79 | RORC (0.36) | RORC | |
| SCHEMBL30163037 | 0.79 | ROCK1 (0.36) | ROCK1RORCTRPV1 | |
| SCHEMBL29218173 | 0.79 | ROCK1 (0.36) | ROCK1RORCTRPV1 | |
| SCHEMBL30163167 | 0.74 | RXRA (0.33) | RORC | |
| SCHEMBL29218232 | 0.74 | NPC1 (0.37) | ROCK1TRPV1ROCK2 | |
| SCHEMBL30163060 | 0.74 | NPC1 (0.37) | ROCK1TRPV1ROCK2 | |
| SCHEMBL30163108 | 0.70 | BUB1 (0.38) | ROCK1RORCTRPV1ROCK2 | |
| SCHEMBL29218235 | 0.70 | BUB1 (0.38) | ROCK1RORCTRPV1ROCK2 | |
| SCHEMBL30162925 | 0.69 | ROCK1 (0.40) | ROCK1 | |
| SCHEMBL29218162 | 0.69 | ROCK1 (0.40) | ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377306-A1 | ROCK2 INHIBITORS AND USES THEREOF | President and Fellows of Harvard College (US) | 2024-06-05 | — | — | EP | disclosed |
| CN-118055926-A | ROCK2 inhibitors and uses thereof | 哈佛大学的校长及成员们 | 2024-05-17 | — | — | CN | disclosed |
| WO-2023009475-A1 | ROCK2 INHIBITORS AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-02-02 | — | — | WO | disclosed |