Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18621626 | 0.85 | LMNA (0.37) | CYP11B1CYP11B2ALDH1A1NOS2KMT2A | |
| SCHEMBL3045111 | 0.83 | NOS2 (0.50) | ALDH1A1POLBNOS2KMT2AMAOB | |
| SCHEMBL17871737 | 0.79 | CYP11B1 (0.43) | CYP11B1CYP11B2ALDH1A1XDHKMT2A | |
| SCHEMBL24074650 | 0.77 | AR (0.46) | CYP11B1CYP11B2ALDH1A1XDHKMT2A | |
| SCHEMBL2585218 | 0.76 | CYP11B1 (0.40) | CYP11B1CYP11B2ALDH1A1XDHPOLB | |
| SCHEMBL11963251 | 0.76 | CYP11B1 (0.61) | CYP11B1CYP11B2ALDH1A1XDH | |
| SCHEMBL177449 | 0.76 | AR (0.53) | CYP11B1CYP11B2ALDH1A1XDH | |
| SCHEMBL6942725 | 0.75 | ACACB (0.41) | ALDH1A1KMT2AMAOAMAOB | |
| SCHEMBL20767348 | 0.75 | AR (0.59) | CYP11B1CYP11B2ALDH1A1POLBNOS2 | |
| SCHEMBL12180757 | 0.74 | CYP11B1 (0.41) | CYP11B1CYP11B2ALDH1A1XDHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159530-A | Compounds for the treatment of pain, in particular neuropathic pain and/or other diseases or disorders associated with AT2R and/or AT2R mediated signalling | 康福治疗有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4377307-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | Confo Therapeutics N.V. (BE) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |