Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2394294 | 1.00 | MBOAT4 (0.45) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6184247 | 0.86 | MBOAT4 (0.45) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7426416 | 0.83 | MBOAT4 (0.42) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17316420 | 0.82 | CCR1 (0.43) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30640933 | 0.82 | CCR1 (0.43) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3526430 | 0.82 | CCR1 (0.43) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9262850 | 0.81 | TSHR (0.56) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7215435 | 0.79 | L3MBTL1 (0.39) | ALDH1A1GAAL3MBTL1GLAHTT | |
| SCHEMBL10271764 | 0.79 | MBOAT4 (0.39) | MBOAT4ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7332467 | 0.78 | PARP1 (0.37) | ALDH1A1GAAL3MBTL1GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377307-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | Confo Therapeutics N.V. (BE) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |