Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 6/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213531 | 0.85 | ADAM17 (0.65) | CHRM4DRD4DRD2ADAM17DRD3 | |
| SCHEMBL24986986 | 0.83 | CKS1B (0.56) | CHRM4DRD4DRD2ADAM17DRD3 | |
| SCHEMBL13622664 | 0.82 | FFAR4 (0.56) | CHRM4DRD4DRD2DRD3GRM5 | |
| SCHEMBL1727869 | 0.82 | KDM4E (0.62) | DRD4DRD2KDM4EALDH1A1HTR2A | |
| SCHEMBL8009381 | 0.81 | CHRM4 (0.49) | CHRM4DRD4DRD2ADAM17CYP2D6 | |
| SCHEMBL2559433 | 0.80 | CHRM4 (0.57) | CHRM4DRD4DRD2ADAM17DRD3 | |
| SCHEMBL31042536 | 0.80 | CHRM4 (0.57) | CHRM4DRD4DRD2ADAM17DRD3 | |
| SCHEMBL31042527 | 0.80 | DRD4 (0.51) | CHRM4DRD4DRD2DRD3KDM4E | |
| SCHEMBL8221362 | 0.79 | ADAM17 (0.66) | CHRM4DRD4DRD2ADAM17DRD3 | |
| SCHEMBL7520833 | 0.79 | CHRM4 (0.49) | CHRM4DRD4DRD2ADAM17DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377307-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | Confo Therapeutics N.V. (BE) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |