SCHEMBL30164264

SCHEMBL30164264

Cc1cnc(CCl)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 1/20 0.46
NOS1 P29475 1/20 0.46
NOS2 P35228 1/20 0.46
HSP90AA1 P07900 1/20 0.40
HSP90AB1 P08238 1/20 0.40
CCR1 P32246 2/20 0.37
CCR5 P51681 2/20 0.37
CCR8 P51685 2/20 0.37
AGBL2 Q5U5Z8 2/20 0.35
CYP1A2 P05177 1/20 0.33
CXCR4 P61073 1/20 0.33
HDAC6 Q9UBN7 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL286660 1.00 NOS3 (0.46) NOS3NOS1NOS2HSP90AA1HSP90AB1
Hydrochloric Acid SCHEMBL1193387 0.98 NOS3 (0.45) NOS3NOS1NOS2HSP90AA1HSP90AB1
Hydrochloric Acid SCHEMBL29861810 0.98 NOS3 (0.45) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL873234 0.79 NOS3 (0.48) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL29384905 0.79 NOS3 (0.48) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL2112705 0.78 S1PR1 (0.39) AGBL2L3MBTL1KDM4EMAPK1KMT2A
SCHEMBL16039165 0.78 CCR1 (0.34) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL29636159 0.78 CCR1 (0.34) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL13196217 0.77 NOS3 (0.46) NOS3NOS1NOS2HSP90AA1HSP90AB1
SCHEMBL17248011 0.77 NOS3 (0.46) NOS3NOS1NOS2HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117720518-B Benzimidazole compound, preparation method thereof, pharmaceutical composition and application 江苏海洋大学 2024-08-13 CN disclosed
CN-118159530-A Compounds for the treatment of pain, in particular neuropathic pain and/or other diseases or disorders associated with AT2R and/or AT2R mediated signalling 康福治疗有限公司 2024-06-07 CN disclosed
EP-4377307-A1 COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING Confo Therapeutics N.V. (BE) 2024-06-05 EP disclosed
CN-117720518-A Benzimidazole compound, preparation method thereof, pharmaceutical composition and application 江苏海洋大学 2024-03-19 CN disclosed
WO-2023006893-A1 COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING CONFO THERAPEUTICS N.V. (BE) 2023-02-02 WO disclosed