Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24810572 | 1.00 | KDM4E (0.40) | KDM4ERAB9ATP53GAAALPG | |
| SCHEMBL30865632 | 0.82 | KAT2B (0.36) | — | |
| SCHEMBL24811599 | 0.82 | — | — | |
| SCHEMBL24811604 | 0.82 | KAT2B (0.36) | — | |
| SCHEMBL30865601 | 0.80 | KCNJ5 (0.37) | HRH4POLBP2RX3P2RX2MAT2A | |
| SCHEMBL24811598 | 0.80 | KCNJ5 (0.37) | HRH4POLBP2RX3P2RX2MAT2A | |
| SCHEMBL30865637 | 0.77 | MAPK1 (0.41) | KDM4EGAAHRH4RAD52 | |
| SCHEMBL24810236 | 0.77 | MAPK1 (0.41) | KDM4EGAAHRH4RAD52 | |
| SCHEMBL29829100 | 0.72 | HRH4 (0.43) | KDM4ERAB9ATP53GAAALPG | |
| SCHEMBL27030702 | 0.72 | HRH4 (0.43) | KDM4ERAB9ATP53GAAALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916232-A | Heterocyclic EGFR inhibitors for the treatment of cancer | 缆图药品公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2022271749-A1 | HETEROCYCLIC EGFR INHIBITORS FOR USE IN THE TREATMENT OF CANCER | BLUEPRINT MEDICINES CORPORATION (US) | 2022-12-29 | — | — | WO | disclosed |