Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 9/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GCKR | Q14397 | 3/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27175853 | 1.00 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3R1 | |
| SCHEMBL30416628 | 0.93 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3R1 | |
| SCHEMBL25181538 | 0.93 | CHRNB2 (0.38) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3R1 | |
| SCHEMBL28958013 | 0.78 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30160982 | 0.78 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25845596 | 0.76 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3GCKR | |
| SCHEMBL21698694 | 0.75 | CCNC (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL29736525 | 0.74 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3R1 | |
| SCHEMBL29618159 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA | |
| SCHEMBL13769145 | 0.74 | CDK1 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |