Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK1D | Q8IU85 | 13/20 | 0.39 |
| ▸ | BTK | Q06187 | 4/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BLK | P51451 | 1/20 | 0.33 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.33 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31052405 | 0.83 | LCK (0.35) | CAMK1DBTKLCKJAK3RIPK4 | |
| SCHEMBL31052385 | 0.83 | LCK (0.35) | CAMK1DBTKLCKJAK3RIPK4 | |
| SCHEMBL30160748 | 0.81 | JAK3 (0.44) | CAMK1DBTKLCKJAK3 | |
| SCHEMBL30165824 | 0.75 | BTK (0.37) | CAMK1DBTKLCKJAK3MAPK1 | |
| SCHEMBL30160804 | 0.74 | JAK3 (0.40) | CAMK1DBTKLCKJAK3PIM1 | |
| SCHEMBL30160681 | 0.73 | JAK3 (0.52) | BTKLCKJAK3 | |
| SCHEMBL30160759 | 0.73 | JAK3 (0.52) | BTKLCKJAK3 | |
| SCHEMBL30165869 | 0.73 | SCN9A (0.47) | BTKLCKJAK3 | |
| SCHEMBL30415191 | 0.72 | HDAC6 (0.44) | CAMK1DRIPK4KCNH2MAP2K5MAP3K11 | |
| SCHEMBL30165816 | 0.72 | JAK3 (0.42) | BTKLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115557933-B | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-115557933-A | Bruton tyrosine kinase and mutant degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-01-03 | — | — | CN | disclosed |