Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.54 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | APLNR | P35414 | 2/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium SCHEMBL30166525 | 1.00 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL717087 | 0.97 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Water SCHEMBL30871968 | 0.95 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL15414791 | 0.95 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL28215757 | 0.95 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL20635078 | 0.88 | APLNR (0.69) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| Hydrochloric Acid SCHEMBL20609810 | 0.86 | APLNR (0.67) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL4717765 | 0.82 | — | — | |
| SCHEMBL22778484 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL31319971 | 0.80 | APLNR (0.72) | GABRA1TSHRGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359386-A1 | A CRYSTALLINE POTASSIUM SALT OF 1-ETHYL- N -((1,2,3,5,6,7-HEXAHYDRO- S -INDACEN-4-YL)CARBAMOYL)PIPERIDINE-4 -SULFONAMIDE | F. Hoffmann-La Roche AG (CH) | 2024-05-01 | — | — | EP | disclosed |
| CN-117545740-A | Crystalline potassium salt of 1-ethyl-N- ((1, 2,3,5,6, 7-hexahydro-symmetrical indacen-4-yl) carbamoyl) piperidine-4-sulfonamide | 豪夫迈·罗氏有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2022269010-A1 | A CRYSTALLINE POTASSIUM SALT OF 1-ETHYL- N -((1,2,3,5,6,7-HEXAHYDRO- S -INDACEN-4-YL)CARBAMOYL)PIPERIDINE-4 -SULFONAMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2022-12-29 | — | — | WO | disclosed |