Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.70 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16027657 | 1.00 | TRPC5 (0.70) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL30171354 | 0.94 | TRPC5 (0.80) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16028521 | 0.94 | TRPC5 (0.80) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16028293 | 0.93 | TRPC5 (0.71) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16028337 | 0.91 | TRPC5 (0.69) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16028445 | 0.91 | TRPC4 (0.67) | TRPC5TRPC4KCNH2TRPC1MEN1 | |
| SCHEMBL16028465 | 0.91 | TRPC5 (0.70) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16028347 | 0.90 | TRPC5 (0.61) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL30171286 | 0.90 | TRPC5 (0.67) | TRPC5TRPC4KCNH2TRPC1TSHR | |
| SCHEMBL16076066 | 0.90 | TRPC5 (0.67) | TRPC5TRPC4KCNH2TRPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250034143-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, LLC (US) | 2025-01-30 | — | — | US | disclosed |
| US-11958854-B2 | Substituted xanthines and methods of use thereof | HYDRA BIOSCIENCES, LLC (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230040259-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES, LLC (US) | 2023-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11958854-B2 | Substituted xanthines and methods of use thereof | TRPC5, TRPC7, TRPC4 | TRPC5 1/4885TRPC4 3/4885KCNH2 70/4885 |
| US-20230040259-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | TRPC5 1/4885TRPC4 3/4885KCNH2 70/4885 |
| US-20250034143-A1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | TRPC5, TRPC7, TRPC4 | TRPC5 1/4885TRPC4 3/4885KCNH2 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.