Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 5/20 | 0.40 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | BCL6 | P41182 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122996 | 1.00 | PTK6 (0.40) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL22124640 | 1.00 | PTK6 (0.40) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL22123050 | 1.00 | PTK6 (0.40) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL30171949 | 1.00 | PTK6 (0.40) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL30171981 | 1.00 | PTK6 (0.40) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL22122941 | 0.99 | PTK6 (0.41) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL30171741 | 0.99 | PTK6 (0.41) | PTK6MAPKAPK5TTKBRAFLRRK2 | |
| SCHEMBL22160965 | 0.93 | PTK6 (0.40) | PTK6KDM4EGAASMN1; SMN2LCK | |
| SCHEMBL22123532 | 0.90 | PTK6 (0.42) | PTK6MAPKAPK5TTKLRRK2BCL6 | |
| SCHEMBL22123658 | 0.90 | PTK6 (0.42) | PTK6MAPKAPK5TTKLRRK2BCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, MYD88, IL1R1 | PTK6 2211/4885MAPKAPK5 647/4885TTK 4482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.