Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 9/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 12/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172435 | 0.87 | AAK1 (0.51) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172452 | 0.85 | AAK1 (0.55) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL15261395 | 0.81 | AAK1 (0.77) | AAK1JAK2JAK3PTK2CSNK2A1 | |
| SCHEMBL30102954 | 0.80 | AAK1 (0.58) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172378 | 0.80 | AAK1 (0.58) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172436 | 0.80 | NTRK1 (0.44) | JAK2NTRK1CSNK2A1CSNK2A2 | |
| SCHEMBL30172462 | 0.79 | AAK1 (0.64) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172444 | 0.77 | AAK1 (0.61) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172451 | 0.77 | AAK1 (0.54) | AAK1JAK2JAK3PTK2NTRK1 | |
| SCHEMBL30172455 | 0.76 | AAK1 (0.60) | AAK1JAK2JAK3PTK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677705-A | AAK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |