Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.44 |
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30172430 | 0.88 | NTRK1 (0.42) | NTRK1JAK2GRM2 | |
| SCHEMBL31441687 | 0.80 | MAP4K4 (0.53) | NTRK1 | |
| SCHEMBL31441513 | 0.80 | MAP4K4 (0.53) | NTRK1 | |
| SCHEMBL30172440 | 0.80 | AAK1 (0.55) | NTRK1JAK2CSNK2A2CSNK2A1 | |
| SCHEMBL31441655 | 0.77 | NR1H2 (0.49) | NTRK1CSNK2A1 | |
| SCHEMBL15261397 | 0.77 | RET (0.52) | — | |
| SCHEMBL30867870 | 0.75 | NR1H2 (0.34) | NTRK1 | |
| SCHEMBL38663358 | 0.72 | GPR119 (0.37) | — | |
| SCHEMBL30172411 | 0.72 | RET (0.44) | NTRK1CSNK2A2CSNK2A1 | |
| SCHEMBL30172456 | 0.71 | RET (0.46) | NTRK1CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115677705-A | AAK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |