Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28379449 | 0.91 | MTOR (0.54) | HDAC1MTORBTKPIK3CDPIK3CA | |
| SCHEMBL28384593 | 0.90 | FYN (0.47) | HDAC1MTORBTKPIK3CDPIK3CA | |
| SCHEMBL28473090 | 0.90 | HDAC1 (0.62) | HDAC1MTORBTKPIK3CDPIK3CA | |
| SCHEMBL30172742 | 0.90 | BTK (0.52) | HDAC1MTORBTKPIK3CDPIK3CA | |
| SCHEMBL30172746 | 0.88 | PDGFRB (0.49) | HDAC1BTKFYN | |
| SCHEMBL28927595 | 0.88 | PDGFRB (0.49) | HDAC1BTKFYN | |
| SCHEMBL28383968 | 0.87 | BTK (0.56) | HDAC1MTORBTKPIK3CDPIK3CA | |
| SCHEMBL28962163 | 0.87 | HDAC1 (0.53) | HDAC1MTORBTKFYN | |
| SCHEMBL28380398 | 0.87 | MTOR (0.50) | HDAC1MTORBTK | |
| SCHEMBL28383609 | 0.87 | BTK (0.56) | HDAC1MTORBTKPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572297-A | O-phenylenediamine derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2023-01-06 | — | — | CN | claimed |
| CN-115572297-B | Pyrazolopyrimidine-containing o-phenylenediamine derivative, and preparation method and application thereof | 山东大学 | 2024-04-26 | — | — | CN | disclosed |
| CN-115572297-A | O-phenylenediamine derivative containing pyrazolopyrimidine and preparation method and application thereof | 山东大学 | 2023-01-06 | — | — | CN | disclosed |