⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292585 | 0.74 | JAK2 (0.44) | — | |
| SCHEMBL17913130 | 0.74 | — | — | |
| SCHEMBL30173057 | 0.70 | CHRNB2 (0.35) | — | |
| SCHEMBL30711685 | 0.69 | MAP3K12 (0.40) | — | |
| SCHEMBL30001152 | 0.68 | PRMT5 (0.35) | — | |
| SCHEMBL20242476 | 0.68 | PRMT5 (0.35) | — | |
| SCHEMBL26585987 | 0.68 | PIK3CA (0.39) | — | |
| SCHEMBL24993450 | 0.66 | CHRNB2 (0.40) | — | |
| SCHEMBL7696565 | 0.66 | CHRNB2 (0.51) | — | |
| SCHEMBL7696569 | 0.66 | CHRNB2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |