Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DEGS1 | O15121 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24992627 | 1.00 | DEGS1 (0.52) | DEGS1ABL1NPC1RAB9ATSHR | |
| SCHEMBL24103799 | 0.81 | DEGS1 (0.58) | DEGS1ABL1NPC1RAB9AALDH1A1 | |
| SCHEMBL23089232 | 0.81 | DEGS1 (0.47) | DEGS1ABL1NPC1RAB9ATSHR | |
| SCHEMBL30865568 | 0.73 | HSD11B1 (0.45) | — | |
| SCHEMBL24992616 | 0.73 | ADORA2A (0.43) | DEGS1ABL1TSHRTP53GSK3B | |
| SCHEMBL24992626 | 0.73 | ROCK2 (0.46) | DEGS1ABL1TSHRMAPTTP53 | |
| SCHEMBL21424095 | 0.73 | DEGS1 (0.49) | DEGS1ABL1NPC1RAB9AKMT2A | |
| SCHEMBL23750583 | 0.72 | MKNK1 (0.52) | DEGS1ABL1KMT2AWNT1GSK3B | |
| SCHEMBL24992622 | 0.71 | TYK2 (0.42) | DEGS1ABL1TSHRMAPTTP53 | |
| SCHEMBL15785485 | 0.70 | MAPT (0.66) | DEGS1NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |