Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234174 | 0.78 | GRM1 (0.38) | AADATGRM1MEN1KMT2AHTR2C | |
| SCHEMBL17951925 | 0.78 | KDM4E (0.41) | GRM1MEN1KMT2AHTR2CALDH1A1 | |
| SCHEMBL21211920 | 0.78 | PIM1 (0.44) | GRM1KMT2ARAB9AMAPK1 | |
| SCHEMBL22151645 | 0.74 | GRM1 (0.38) | AADATGRM1MEN1KMT2ACYP3A4 | |
| SCHEMBL21211936 | 0.74 | HTR2C (0.46) | MEN1KMT2AHTR2CCES1 | |
| SCHEMBL17517182 | 0.74 | IDH1 (0.46) | GRM1KMT2AHTR2CALDH1A1KDM4E | |
| SCHEMBL21025963 | 0.74 | IDH1 (0.43) | GRM1MEN1KMT2AHTR2CALDH1A1 | |
| SCHEMBL31303406 | 0.74 | GRM1 (0.40) | AADATGRM1MEN1KMT2AALDH1A1 | |
| SCHEMBL2025720 | 0.71 | DHPS (0.60) | MEN1KMT2ACYP3A4ALDH1A1LMNA | |
| SCHEMBL31019490 | 0.68 | KMT2A (0.63) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117295737-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2023-12-26 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |