Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24992624 | 1.00 | AAK1 (0.35) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL24993465 | 0.83 | GSK3B (0.34) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL30865560 | 0.83 | GSK3B (0.34) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL30630161 | 0.83 | PIK3CA (0.36) | AAK1GSK3BDYRK1AMAPKAPK2GHSR | |
| SCHEMBL23104424 | 0.83 | PIK3CA (0.36) | AAK1GSK3BDYRK1AMAPKAPK2GHSR | |
| SCHEMBL23104024 | 0.82 | GSK3B (0.34) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL29736433 | 0.82 | GSK3B (0.34) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL23103813 | 0.79 | GSK3B (0.37) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL29814648 | 0.79 | GSK3B (0.37) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 | |
| SCHEMBL23089327 | 0.77 | ATR (0.44) | AAK1GSK3BDYRK1ASCN9AMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250011331-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2025-01-09 | — | — | US | disclosed |
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250011331-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | AAK1 44/4885GSK3B 537/4885DYRK1A 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.