Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | RORB | Q92753 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23782403 | 1.00 | NOTUM (0.43) | NOTUMDHODHRORBKDRPDGFRB | |
| SCHEMBL30176213 | 0.90 | KDM4E (0.39) | NOTUMDHODHKDM4EMAPT | |
| SCHEMBL23782609 | 0.90 | KDM4E (0.39) | NOTUMDHODHKDM4EMAPT | |
| SCHEMBL26242059 | 0.88 | DHODH (0.36) | NOTUMDHODHKDM4EBLMMAPT | |
| SCHEMBL23792482 | 0.82 | ALDH1A1 (0.38) | NOTUMDHODHKDM4EMAPTTRPV1 | |
| SCHEMBL23782503 | 0.81 | NOTUM (0.44) | NOTUMDHODHRORBKDRPDGFRB | |
| SCHEMBL30176220 | 0.81 | NOTUM (0.44) | NOTUMDHODHRORBKDRPDGFRB | |
| SCHEMBL30173772 | 0.81 | DHODH (0.45) | NOTUMDHODHRORBKDRRAPGEF3 | |
| SCHEMBL23782401 | 0.81 | DHODH (0.45) | NOTUMDHODHRORBKDRRAPGEF3 | |
| SCHEMBL23791998 | 0.79 | DHODH (0.46) | NOTUMDHODHRORBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4114529-A1 | EIF4E INHIBITORS AND USES THEREOF | PIC Therapeutics, Inc. (US) | 2023-01-11 | — | — | EP | disclosed |